Dimethylformamide → 4-(2,6-difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

関与物質

役割	名称	HCID	仕込み量
反応物	Dimethylformamide	HCID 6228	—
反応物	Potassium Carbonate	HCID 11430	—
反応物	2,6-Difluoro-4-methoxybenzyl bromide	HCID 3354272	—
反応物	2-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide	HCID 72722085	—
生成物	4-(2,6-difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide	HCID 72722089	—

反応手順

The title compound (97 mg, 0.20 mmol) was prepared from (IntA19) (84 mg, 0.25 mmol), K2CO3 (104 mg, 0.75 mmol) and 2,6-difluoro-4-methoxybenzyl bromide (71 mg, 0.30 mmol) in DMF (2 mL) using the methods of (115).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09249160B2
出典データセット	uspto-grants-2016_02
ORD ID	ord-9ce6febde71645389d0e3d5c581c0c78
出典メモ	uspto-grants-2016_02