HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → 4-(2-Chloro-6-fluorobenzyl)-2-(4-hydroxy-3,5-di methyl phenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 4-(2-Chloro-6-fluorobenzyl)-2-(4-methoxy-3,5-dimethylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide | HCID 72721275 | — |
| Reactant | 2-(4-Hydroxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide | HCID 72721895 | — |
| Product | 4-(2-Chloro-6-fluorobenzyl)-2-(4-hydroxy-3,5-di methyl phenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide | HCID 72721988 | 54.2% |
Reaction Steps
The title compound (0.12 g, 0.26 mmol) was prepared from (81) (0.23 g, 0.48 mmol) and boron tribromide (1.0M solution in DCM, 0.60 mL, 0.60 mmol) using the methods of (114).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249160B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-dfb982258ce642ada7b089db16857294 |
| Source note | uspto-grants-2016_02 |