Potassium Carbonate → 4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethylpyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Potassium Carbonate	HCID 11430	—
Edukt	2,6-Difluoro-4-methoxybenzyl bromide	HCID 3354272	—
Edukt	2-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide	HCID 72722085	—
Edukt	2-(5,6-dimethylpyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide	HCID 90055123	—
Lösungsmittel	Dimethylformamide	HCID 6228	—
Produkt	4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethylpyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide	HCID 72720879	26,5%

Reaktionsschritte

The title compound (58 mg, 0.13 mmol) was prepared from 2-(5,6-dimethylpyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide (IntA29) (150 mg, 0.49 mmol), 2,6-difluoro-4-methoxybenzyl bromide (129 mg, 0.54 mmol) and K2CO3 (102 mg, 0.74 mmol) in DMF (3 mL) at 50° C. using the methods of (115).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09249160B2
Quelldatensatz	uspto-grants-2016_02
ORD ID	ord-f60e81471cb940dfb5342ce7d0065a05
Quellennotiz	uspto-grants-2016_02