HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 131734702, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,6-Difluoro-4-methoxybenzyl bromide | HCID 3354272 | — |
| Reactant | 2-(4-methoxy-3,5-dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide | HCID 72722085 | — |
| Reactant | HCID 131734689 | HCID 131734689 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131734702 | HCID 131734702 | 64.6% |
Reaction Steps
The title compound (301 mg, 0.51 mmol) was prepared from tert-butyl[6-(1,1-dioxido-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazin-2-yl)-3-methoxypyridin-2-yl]methylcarbamate (IntA31) (343 mg, 0.79 mmol), 2,6-difluoro-4-methoxybenzyl bromide (225 mg, 0.95 mmol) and K2CO3 (164 mg, 1.19 mmol) in DMF (4 mL) at rt using the methods of (115).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249160B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-ef8909a1cd904319b5f129375fd22a0f |
| Source note | uspto-grants-2016_02 |