Triethylamine → 4-(2-Chloro-6-fluorobenzyl)-2-(2-methoxypyrimidin-5-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	1,1'-Carbonyldiimidazole	HCID 68263	—
Reactant	4-(2-Chloro-6-fluorobenzyl)-2-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide	HCID 90054672	—
Product	4-(2-Chloro-6-fluorobenzyl)-2-(2-methoxypyrimidin-5-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide	HCID 90055063	—

Reaction Steps

The title compound (40 mg, 0.09 mmol) was prepared from (IntB2) (106 mg), 1,1′-carbonyldiimidazole (162 mg, 1.0 mmol) and triethylamine (0.07 mL, 0.50 mmol) using the methods of (132).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09249160B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-1150f7f378e04adda39c4bdfc478f6e1
Source note	uspto-grants-2016_02