Dimethylformamide → 2-(3,5-Dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	Triethylamine	HCID 8471	—
Reactant	1,1'-Carbonyldiimidazole	HCID 68263	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	2,4,6-Trifluorobenzylamine	HCID 2777046	—
Reactant	4-(2,6-difluoro-4-methoxybenzyl)-2-(3,4-dimethoxyphenyl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3 (4H)-one 1,1-dioxide	HCID 90054671	—
Product	2-(3,5-Dimethylphenyl)-4-(2,4,6-trifluorobenzyl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide	HCID 72721892	—

Reaction Steps

The title compound (89 mg, 0.20 mmol) was prepared in two steps from (IntC6) (209 mg, 0.71 mmol), 2,4,6-trifluorobenzylamine (107 uL, 0.88 mmol) and N,N-diisopropylethylamine (252 uL, 1.41 mmol); followed by 1,1′-carbonyldiimidazole (386 mg, 2.38 mmol) and triethylamine (114 uL, 0.82 mmol) in DMF (9.5 mL) using the methods of (95).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09249160B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-d9761fc55c944257babd43b0c7b38a67
Source note	uspto-grants-2016_02