Cesium carbonate → HCID 90055060, compound

HRID 1772990Notes

Reaction equation

HRID 1772990 reaction equation
Br[CH2:2][C:3]1([CH3:7])[CH2:6][O:5][CH2:4]1.C([O-])([O-])=O.[Cs+].[Cs+].[Cl:14][C:15]1[CH:41]=[CH:40][CH:39]=[C:38]([F:42])[C:16]=1[CH2:17][N:18]1[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[S:21](=[O:29])(=[O:28])[N:20](CC2C=CC=CN=2)[C:19]1=[O:37]>>[Cl:14][C:15]1[CH:41]=[CH:40][CH:39]=[C:38]([F:42])[C:16]=1[CH2:17][N:18]1[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[S:21](=[O:29])(=[O:28])[N:20]([CH2:2][C:3]2([CH3:7])[CH2:6][O:5][CH2:4]2)[C:19]1=[O:37]

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 144860Oxetane, 3-(bromomethyl)-3-methyl-HCID 90054655HCID 90054655, compound

Product 1

HCID 90055060HCID 90055060, compound

Procedure

The title compound (123 mg, 0.29 mmol) was prepared from (IntE1) (0.3 g, 0.88 mmol), 3-(bromomethyl)-3-methyloxetane (0.21 g, 1.32 mmol) and Cs2CO3 (0.86 g, 2.64 mmol) using the methods of (128).

Sources & evidence

ORD record
ord-c1eaeb8ceb7b40ae8f1053092ecc3edb
Source dataset
uspto-grants-2016_02
Patent number
US09249160B2

Reaction notes

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