Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2'-Hydroxybenzophenone | HCID 8348 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Product | HCID 87071169 | HCID 87071169 | — |
Reaction Steps
Hydroxybenzophenone (918 μmol) and 1,8-naphthalene derivative (1380 μmol) are dissolved in 1.5 mL of methanesulfonic acid, then 1.5 mL of trifluoroacetic acid (TFA) are added. The mixture is heated and stirred at 80° C. for 16-24 hours. The reaction mixture is allowed to warm to room temperature, and then poured into 50 mL of deionized (DI) water. The mixture is neutralized to pH 6-7 by portion-wise addition of solid NaHCO3. The resulting precipitate is filtered, washed with DI water and air dried. The target compound is isolated by flash column chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09250246B2 |
|---|
| Source dataset | uspto-grants-2016_02 |
|---|
| ORD ID | ord-289f22f77cc945e191125da34e66965d |
|---|
| Source note | uspto-grants-2016_02 |
|---|
