4-Methylquinoline → HCID 68587788, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of lepidine (3.0 g, 21 mmol) and 3-bromopropylamine hydrobromide (4.6 g, 21 mmol) in 1,2-dichlorobenzene (50 mL) was heated at 135° C. for 16 hours. The mixture was cooled and 1,2-dichlorobenzene was decanted. The residue thus obtained was suspended in methanol (25 mL) and refluxed for 10 min. It was cooled and separated solid was collected by centrifugation, washed with methanol (2×30 mL) and dried under high vacuum to yield Compound 2 as an light gray solid (1.4 g, 19%). This product was used without further purification. The structure of Compound 1 is given below:

Provenance & Evidence