Water → HCID 85524395, compound

Participants

Reaction Steps

Phenothiazine (5.0 g, 0.025 mol) and 1,6-dibromohexane (10.0 g, 0.065 mol) were dissolved in 100 mL of DMF (dimethyl formamide), and NaOH (sodium hydride, 0.98 g, 0.041 mol) was slowly added at room temperature. The resulting mixture was stirred at room temperature for 8 hr. After completion of the reaction, work-up was implemented in a solvent mixture of water and CHCl3 at 1:1. Thereafter, the organic layer was separated using an extraction method, and the solvent was removed under reduced pressure, followed by silica gel column chromatography (chloroform:hexane, 1:5), affording a transparent liquid product (4.5 g, 49.7%).

Provenance & Evidence