反应详情

0.54 g of TEBAC (2.4×10−3 mol) and 5.6 g of CEVE (0.05 mol) are added to a solution of 1-benzyl-2-hydroxymethylimidazole (4.7 g, 0.024 mol.) in toluene (15 ml). A basic solution 20 N in NaOH (100 ml) is then added in the medium and the heterogeneous mixture is brought to 90° C. for 24 h with vigorous stirring. After cooling, the solution is diluted with 250 ml of decanted ether, then the organic phase is washed with water until pH=7 (10×100 ml). The organic phase is dried on Na2SO4, filtered, then evaporated under reduced pressure to yield 5.3 g (85%) of desired product. Given the satisfactory purity of the obtained product, no further purification is required.

1. temperatureAfter cooling
2. washthe organic phase is washed with water until pH=7 (10×100 ml)
3. customThe organic phase is dried on Na2SO4
4. filtrationfiltered
5. customevaporated under reduced pressure