2,4-Dihydroxybenzylamine → 5-adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2-hydroxy-4-methoxybenzamide

HRID 1773071Notes

Reaction equation

HRID 1773071 reaction equation
[C:1]12([C:11]3[C:12]([O:21][CH3:22])=[CH:13][C:14]([OH:20])=[C:15]([CH:19]=3)[C:16](O)=[O:17])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[OH:23][C:24]1[CH:31]=[C:30]([OH:32])[CH:29]=[CH:28][C:25]=1[CH2:26][NH2:27]>>[C:1]12([C:11]3[C:12]([O:21][CH3:22])=[CH:13][C:14]([OH:20])=[C:15]([CH:19]=3)[C:16]([NH:27][CH2:26][C:25]3[CH:28]=[CH:29][C:30]([OH:32])=[CH:31][C:24]=3[OH:23])=[O:17])[CH2:2][CH:3]3[CH2:9][CH:7]([CH2:6][CH:5]([CH2:4]3)[CH2:10]1)[CH2:8]2

Participants

3

Reactant 2

HCID 1249932,4-DihydroxybenzylamineHCID 150525875-Adamantan-1-yl-2-hydroxy-4-methoxybenzoic acid

Product 1

HCID 573286165-adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2-hydroxy-4-methoxybenzamide

Procedure

0.14 g of the target compound is obtained as solid of a light color in substantially the same manner as in (2) of Example 1, except for using 5-adamantan-1-yl-2-hydroxy-4-methoxybenzoic acid instead of 5-adamantan-1-yl-2,4-dihydroxybenzoic acid and using 2,4-dihydroxybenzylamine instead of dopamine.

Sources & evidence

ORD record
ord-0d8a4ce400174d309362eb5c2cf06fd6
Source dataset
uspto-grants-2016_02
Patent number
US09254251B2

Reaction notes

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