2,4-Dihydroxybenzylamine → 5-adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide

HRID 1773072Notes

Reaction equation

HRID 1773072 reaction equation
[C:1]12([C:11]3[C:12]([O:22][CH3:23])=[CH:13][C:14]([O:20][CH3:21])=[C:15]([CH:19]=3)[C:16](O)=[O:17])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[OH:24][C:25]1[CH:32]=[C:31]([OH:33])[CH:30]=[CH:29][C:26]=1[CH2:27][NH2:28]>>[C:1]12([C:11]3[C:12]([O:22][CH3:23])=[CH:13][C:14]([O:20][CH3:21])=[C:15]([CH:19]=3)[C:16]([NH:28][CH2:27][C:26]3[CH:29]=[CH:30][C:31]([OH:33])=[CH:32][C:25]=3[OH:24])=[O:17])[CH2:2][CH:3]3[CH2:9][CH:7]([CH2:6][CH:5]([CH2:4]3)[CH2:10]1)[CH2:8]2

Participants

3

Reactant 2

HCID 1249932,4-DihydroxybenzylamineHCID 148525305-Adamantan-1-yl-2,4-dimethoxybenzoic acid

Product 1

HCID 573286155-adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide

Procedure

0.03 g of the target compound is obtained as white solid in substantially the same manner as in (2) of Example 1, except for using 5-adamantan-1-yl-2,4-dimethoxybenzoic acid instead of 5-adamantan-1-yl-2,4-dihydroxybenzoic acid and using 2,4-dihydroxybenzylamine instead of dopamine.

Sources & evidence

ORD record
ord-401067cc63e94cf09d3577799bad7c99
Source dataset
uspto-grants-2016_02
Patent number
US09254251B2

Reaction notes

Loading…