2,4-Dihydroxybenzylamine → 3-adamantan-1-yl-N-(2,4-dihydroxybenzyl)-4-methoxybenzamide

HRID 1773076Notes

Reaction equation

HRID 1773076 reaction equation
[C:1]12([C:11]3[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[C:14](O)=[O:15])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[OH:22][C:23]1[CH:30]=[C:29]([OH:31])[CH:28]=[CH:27][C:24]=1[CH2:25][NH2:26]>>[C:1]12([C:11]3[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[C:14]([NH:26][CH2:25][C:24]3[CH:27]=[CH:28][C:29]([OH:31])=[CH:30][C:23]=3[OH:22])=[O:15])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

3

Reactant 2

HCID 1249932,4-DihydroxybenzylamineHCID 52965033-(1-Adamantyl)-4-methoxybenzoic acid

Product 1

HCID 706852173-adamantan-1-yl-N-(2,4-dihydroxybenzyl)-4-methoxybenzamide

Procedure

0.03 g of the target compound is obtained as white solid in substantially the same manner as in Example 11, except for using 3-adamantan-1-yl-4-methoxybenzoic acid instead of 3-adamantan-1-yl-4-hydroxybenzoic acid and using 2,4-dihydroxybenzylamine instead of 3,4-dihydroxybenzylamine.

Sources & evidence

ORD record
ord-e999cc19fb5147a5b551193eab16d645
Source dataset
uspto-grants-2016_02
Patent number
US09254251B2

Reaction notes

Loading…