反应详情

To 127 mg (0.5 mmol) of (2S)-3-amino-2-{[(tert-butoxy)carbonyl]amino}propanoic acid methylester hydrochloride, 87 mg (0.5 mmol) of 3-aminobenzenesulfonic acid and 97 mg (0.6 mmol) of N,N-carbonyl diimidazole, 1 ml of methylene chloride and 1 ml of tetrahydrofuran were added and stirred at room temperature overnight. After distilling the solvent away, purification was carried out using purification step A to obtain a crude purified substance of the title compound in protected form. To the obtained crude purified substance, 1 ml of methylene chloride and 1 ml of trifluoroacetic acid were added and stirred at room temperature for 5 hours. After distilling the solvent away, purification was carried out by purification step A to obtain the title compound.

1. distillationAfter distilling the solvent away
2. custompurification
3. custompurification step A
4. customto obtain a crude
5. custompurified substance of the title compound in protected form
6. customTo the obtained crude
7. custompurified substance, 1 ml of methylene chloride and 1 ml of trifluoroacetic acid
8. additionwere added
9. stirringstirred at room temperature for 5 hours
10. distillationAfter distilling the solvent away
11. custompurification
12. customwas carried out by purification step A