3-Ethylaniline → HCID 118699717, compound

HRID 1773304Notes

Reaction equation

[CH2:1]1[CH2:10][N:9]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14](O)=[O:15])[CH2:8][C:7]2[CH:6]=[N:5][C:4]3[CH:20]=[CH:21][CH:22]=[CH:23][C:3]=3[C:2]1=2.[CH2:24]([C:26]1[CH:27]=[C:28]([CH:30]=[CH:31][CH:32]=1)[NH2:29])[CH3:25]>>[CH2:1]1[CH2:10][N:9]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14]([NH:29][C:28]2[CH:30]=[CH:31][CH:32]=[C:26]([CH2:24][CH3:25])[CH:27]=2)=[O:15])[CH2:8][C:7]2[CH:6]=[N:5][C:4]3[CH:20]=[CH:21][CH:22]=[CH:23][C:3]=3[C:2]1=2

Participants

Reactant 2

HCID 114753-Ethylaniline

HCID 118699718HCID 118699718, compound

Product 1

HCID 118699717HCID 118699717, compoundYield 53%

Procedure

In a manner similar to Example 3, 3-(1,4-dihydrobenzo[c]-2,7-naphthyridin-3(2H)-yl)benzoic acid (0.20 mmol, 61 mg) and 3-ethylaniline (0.30 mmol, 0.037 mL) were reacted to give the title compound as an off-white solid (43 mg, 53%).

Sources & evidence

ORD record: ord-77f62669f5184615b03f94f468ae11ed
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09255096B1

Reaction notes

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