Hydrochloric Acid → HCID 118035228, compound

Participants

Reaction Steps

The compound 1-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-amino-piperidin-1-yl]-xanthine 1 (60 mg, 0.124 mmol) was dissolved in dichloromethane (2 ml). A dichloromethane solution (1 mol/L) of 0.14 ml hydrogen chloride was added to obtain a reaction mixture. The reaction mixture was stirred for 10 minutes, and the solvent was distilled off. The residue was washed with ethyl acetate, and dried, to obtain the target compound 1-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-amino-piperidin-1-yl]-xanthine hydrochloride 4 (47 mg, yellow solid), yield: 76%.

Provenance & Evidence