Isobutyl iodide → HCID 24780065, compound

HRID 1773336Notes

Reaction equation

HRID 1773336 reaction equation
[F:1][C:2]1[CH:32]=[CH:31][C:5]([CH2:6][NH:7][C:8]2[N:9]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=3)[N:10]=[C:11]3[C:16]=2[C:15](=[O:17])[N:14]([CH3:18])[C:13](=[O:19])[NH:12]3)=[CH:4][CH:3]=1.[CH2:33](I)[CH:34]([CH3:36])[CH3:35].IC1CCCC1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C:8]2[N:9]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:28])([F:30])[F:29])=[CH:23][CH:22]=3)[N:10]=[C:11]3[C:16]=2[C:15](=[O:17])[N:14]([CH3:18])[C:13](=[O:19])[N:12]3[CH2:33][CH:34]([CH3:36])[CH3:35])=[CH:31][CH:32]=1

Participants

4

Reactant 3

HCID 10556Isobutyl iodideHCID 73784IodocyclopentaneHCID 136388726HCID 136388726, compound

Product 1

HCID 24780065HCID 24780065, compound

Procedure

The synthesis method is analogous to example 7 wherein 3-(4-fluorobenzylamino)-5-methyl-2-(4-(trifluoromethyl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione is used instead of 5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione, and isobutyl iodide is added instead of iodocyclopentane. MS (ESI) m/z 490.2 [M+H]+

Workup

  1. customThe synthesis method

Sources & evidence

ORD record
ord-43574fe4be2e41028c6638f025627a6a
Source dataset
uspto-grants-2016_02
Patent number
US09255099B2

Reaction notes

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