Dimethylformamide → HCID 118483162, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of {1-[5-chloro-4-(4-cyano-3-fluoro-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl]-piperidin-4-yl}-carbamic acid tert-butyl ester (460 mg, 1 mmol), Zn(CN)2 (175 mg, 1.5 mmol) and Pd(PPh3)4 (116 mg, 0.0.1 mmol) in DMF (5 mL) was stirred 4 h at 150° C. under N2 atmosphere. The mixture was cooled to RT and filtered. The filtrate was concentrated in vacuo, and the residue purified by preperative HPLC to give 150 mg of the title product as a yellow solid (33%). [M+H] Calc'd for C23H25FN6O3, 453. Found, 453.

Provenance & Evidence