HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Cyano-3-fluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Cyano-3-fluorobenzoic acid | HCID 2778468 | — |
| Product | 4-Cyano-3-fluorobenzoyl chloride | HCID 19956739 | 99% |
Reaction Steps
A mixture of 4-cyano-3-fluoro-benzoic acid (2.0 g, 12.12 mmol) in SOCl2 (20 mL) was refluxed for 2 h, and SOCl2 was removed in vacuo to give 4-cyano-3-fluoro-benzoyl chloride (2.2 g, 99%). The crude was carried to the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09255097B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-71b94d3b50a94d98bc4ea4d07b409500 |
| Source note | uspto-grants-2016_02 |