HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178420916, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 15056 | HCID 15056 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178420916 | HCID 178420916 | — |
Reaction Steps
The raw materials S (1 eq) and amine D (1 eq) which are commercially purchased or synthesized are dissolved in DMF, and then HBTU and DIPEA are sequentially added in an ice bath. The resultant mixture is gradually warmed up to room temperature and stirred overnight. Water is added into the mixture in an ice bath, and the resulting mixture is extracted with dichloromethane. The dichloromethane layer is washed with saturated aqueous sodium chloride, dried, and evaporated to remove solvent. The residue is separated by column chromatography to obtain piperazinotriazole compounds as shown in formula I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09255106B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-5ad6259384c64a6cbec164883af5b95f |
| Source note | uspto-grants-2016_02 |