HCID 68617344, compound → HCID 118412729, compound

HRID 1773472Notes

Reaction equation

HRID 1773472 reaction equation
Br[N:2]1[C:6]2[N:7]=[CH:8][CH2:9][NH:10][C:5]=2[CH:4]=[CH:3]1.[C:11]([C:13]1[CH:14]=[C:15]([NH:20][C:21]([NH:23][C:24]2[CH:29]=[CH:28][C:27]([CH2:30][N:31]3[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]3)=[C:26]([C:38]([F:41])([F:40])[F:39])[CH:25]=2)=[O:22])[CH:16]=[CH:17][C:18]=1[CH3:19])#[CH:12]>>[NH:10]1[CH2:9][CH:8]=[N:7][C:6]2[N:2]([C:12]#[C:11][C:13]3[CH:14]=[C:15]([NH:20][C:21]([NH:23][C:24]4[CH:29]=[CH:28][C:27]([CH2:30][N:31]5[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]5)=[C:26]([C:38]([F:41])([F:39])[F:40])[CH:25]=4)=[O:22])[CH:16]=[CH:17][C:18]=3[CH3:19])[CH:3]=[CH:4][C:5]1=2

Participants

3

Reactant 2

HCID 68617344HCID 68617344, compoundHCID 118107787HCID 118107787, compound

Product 1

HCID 118412729HCID 118412729, compound

Procedure

The title compound was prepared using 5-bromo-1H-pyrrolo[2,3-b]pyrazine and N-(3-ethynyl-4-methylphenyl)-N′-[4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl]urea as raw materials, according to the method described in Step 4 of Example 1.

Sources & evidence

ORD record
ord-ef00a3533f91416ca2bc03b4578fab29
Source dataset
uspto-grants-2016_02
Patent number
US09255107B2

Reaction notes

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