HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1773509Generated: November 1, 2026
Formamide → 7-methyl-3H,4H-thieno[3,2-d]pyrimidin-4-one
https://huagongshe.com/reaction/1773509
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Methyl 3-amino-4-methylthiophene-2-carboxylate | HCID 123584 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-methyl-3H,4H-thieno[3,2-d]pyrimidin-4-one | HCID 135439636 | — |
Reaction Steps
A mixture of 3-amino-4-methyl-thiophene-2-carboxylic acid methyl ester (3.0 g) and formamide (50 mL) was heated to 150° C. overnight. The reaction mixture was then cooled and diluted with water. The solid formed was collected by filtration, washed with water and dried under reduced pressure to give 2.1 g of 7-methyl-3H-thieno[3,2-d]pyrimidin-4-one without further purifications.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09255110B2 |
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| Source dataset | uspto-grants-2016_02 |
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| ORD ID | ord-ce1ca7ac171041ddb0757252373904d1 |
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| Source note | uspto-grants-2016_02 |
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