Formamide → HCID 136385527, compound

HRID 1773528Notes

Reaction equation

HRID 1773528 reaction equation
C[O:2][C:3]([C:5]1[N:9]([NH2:10])[C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:7][CH:6]=1)=O.[CH:16]([NH2:18])=O>O>[CH2:14]([O:13][C:11]([C:8]1[N:9]2[C:5]([C:3](=[O:2])[NH:18][CH:16]=[N:10]2)=[CH:6][CH:7]=1)=[O:12])[CH3:15]

Participants

4

Reactant 2

HCID 713FormamideHCID 66664893HCID 66664893, compound

Product 1

HCID 136385527HCID 136385527, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 1-amino-1H-pyrrole-2,5-dicarboxylic acid 2-ethyl ester 5-methyl ester (140 mg) and formamide (1 mL) was stirred at 140° C. overnight. The reaction mixture was then cooled and diluted with water, the solid which crashed out was collected by filtration and dried under vacuum to give 60 mg of 4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-7-carboxylic acid ethyl ester.

Workup

  1. temperatureThe reaction mixture was then cooled
  2. filtrationthe solid which crashed out was collected by filtration
  3. customdried under vacuum

Sources & evidence

ORD record
ord-eaadaa97f95542b7a97b936ace106e05
Source dataset
uspto-grants-2016_02
Patent number
US09255110B2

Reaction notes

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