Propanedioic acid, 2-(5-chloro-2,4-dinitrophenyl)-, 1-(1,1-dimethylethyl) 3-ethyl ester → HCID 86661369, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-(5-chloro-2,4-dinitro-phenyl)-malonic acid tert-butyl ester ethyl ester (0.4 g) in a mixture of dichloromethane (3 mL) and trifluoroacetic acid (0.5 mL) was heated at 70° C. for 30 minutes in a sealed tube. The reaction mixture was then evaporated under reduced pressure and the residue was purified by flash chromatography (EtOac/hexane, 10/90) to afford 150 mg of (5-chloro-2,4-dinitro-phenyl)-acetic acid ethyl ester.

Provenance & Evidence