反应详情

温度

-20 °C

Fuming nitric acid (150 mL) was slowly added, at −50° C., over a period of 50 minutes to N-(3-chloro-phenyl)-acetamide (45 g). The reaction mixture was allowed to warm up to −20° C. and then was poured into ice-water. The solid formed was collected by filtration, washed with water, and dried under reduced pressure. The residue was washed with dichloromethane and dried under reduced pressure to afford 14 g of N-(3-chloro-4-nitro-phenyl)-acetamide as a light pink solid.

1. customThe solid formed
2. filtrationwas collected by filtration
3. washwashed with water
4. customdried under reduced pressure
5. washThe residue was washed with dichloromethane
6. customdried under reduced pressure