HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 56646549, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid | HCID 1910189 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 58056088 | HCID 58056088 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 56646549 | HCID 56646549 | — |
Reaction Steps
5-Chloro-2-(2-triisopropylsilanyl-oxazol-5-ylmethoxy)-phenylamine was coupled with pyrazolo[1,5-a]pyrimidine-3-carboxylic acid in presence of HBTU as described in Example 1. The product was deprotected by heating with an aqueous solution of sodium hydroxide in methanol for 2 hours. The reaction mixture was cooled; the solid formed was collected by filtration and washed with water. The crude residue was purified by flash chromatography to give 18 mg of pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-chloro-2-(oxazol-5-ylmethoxy)-phenyl]-amide as an off-white solid. MS=370 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09255110B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-f6b6b7ac26b346cbaeb7636c742c0ecd |
| Source note | uspto-grants-2016_02 |