Water → HCID 66695632, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 105 mg (223 μmol) of N-cyclopropyl-2-methyl-4-{8-[(2-methylpropyl)amino]-6-(phenylsulfanyl)imidazo[1,2-b]pyridazin-3-yl}benzamide, which was prepared according to example 197, in 15 mL of DMF was added and 684 mg (1113 μmol) OXONE (potassium peroxymonosulfate) in small portions. The mixture was stirred over night, then cooled to 0° C. and poured onto 200 mL of cold water. The precipitate was collected and purified with normal phase chromatography to yield 97 mg of the title compound as a yellow solid.

Provenance & Evidence