Trifluoroacetic acid → [4-Fluoro-2-(hydroxymethyl)phenyl]boronic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of 2.60 g (7.97 mmol) (4-fluoro-2-{[(triisopropylsilyl)oxy]methyl}phenyl)boronic acid which was prepared according to intermediate example 299b in 10 mL dichloromethane were added 6.14 mL trifluoroacetic acid and the mixture was stirred for 16 hours at 23° C. The solvent was removed and the residue crystallized from n-hexane to give 682 mg (50%) of the title compound.

Provenance & Evidence