Water → HCID 66695745, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 90 mg (153 μmol) ert-butyl {6-(cyclopentylamino)-3-[4-(cyclopropylcarbamoyl)-3-methylphenyl]imidazo[1,2-b]pyridazin-8-yl}(3,3,3-trifluoropropyl)carbamate which was prepared according to intermediate example 453a in 1 mL dichloromethane were added 177 μL trifluoroacetic acid and the mixture was stirred for 2 hours at 23° C. The mixture was poured into water and extracted with dichloromethane. The organic phase was washed with sodium hydrogencarbonate solution and dried over sodium sulfate. After filtration and removal of solvent the residue was purified by chromatography to give 64.1 mg (82%) of the title compound.

Provenance & Evidence