HCID 86705357, compound → HCID 68090513, compound

Participants

Reaction Steps

To a stirred solution of 24 mg (50 μmol) 4-{6-bromo-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl}-N-cyclopropyl-2-methylbenzamide which was prepared according to intermediate example 247a in 1 mL THF is dropwise added 1.0 mL (0.5 mmol) of a 0.5 M solution of bromo(1-phenylethenyl)magnesium in THF at rt. After stirring overnight at rt, the mixture is heated at 50° C. and stirred for 3 more days to give after working up and purification 1.7 mg (5%) of the title compound.

Provenance & Evidence