Dimethylformamide → HCID 66695753, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 4.96 g (11.06 mmol) N-cyclopropyl-4-[6-(3-fluorophenoxy)-8-(methylsulfanyl)imidazo[1,2-b]pyridazin-3-yl]-2-methylbenzamide which was prepared according to intermediate example 486b in DMF (250 mL) were added 20.4 g (33.18 mmol) oxone in one portion at rt. After reaction for 72 h, further 30 g (55 mmol) oxone are added and the mixture is heated at 70° C. for one hour. Extraction with ethyl acetate/water, filtration of the organic phase through a Whatman filter and evaporation of the organic phase yielded the crude product (4.96 g, 93%) which was used without further purification.

Provenance & Evidence