HCID 117601900, compound → HCID 117601684, compound

Participants

Reaction Steps

A suspension of 6-(3,5-dimethylisoxazol-4-yl)-4-(1-(4-fluorophenyl)vinyl)-1H-benzo[d]imidazol-2(3H)-one (60 mg, 0.172 mmol) and 10% palladium on carbon (20 mg) in 5 mL ethanol was purged with hydrogen gas and allowed to stir for 2 hours. The reaction mixture was then filtered and the solvents evaporated. Residue was purified by preparative HPLC which afforded 6-(3,5-dimethylisoxazol-4-yl)-4-(1-(4-fluorophenyl)ethyl)-1H-benzo[d]imidazol-2(3H)-one.

Provenance & Evidence