Tetrahydrofuran → HCID 117601430, compound

Participants

Reaction Conditions

Reaction Steps

To a flask containing 4-(3,5-dimethylisoxazol-4-yl)-6-iodo-N1-methylbenzene-1,2-diamine (299 mg, 0.87 mmol, 1 equiv) was added THF (8 mL) and CDI (282 mg, 1.74 mmol, 2 equiv). The reaction mixture was heated for 2 hr at 120° C. The reaction mixture was then concentrated in vacuo and the solid triturated with diethyl ether to furnish 5-(3,5-dimethylisoxazol-4-yl)-7-iodo-1-methyl-1H-benzo[d]imidazol-2(3H)-one as a light yellow solid.

Provenance & Evidence