Tetrahydrofuran → HCID 117601430, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 4-(3,5-dimethylisoxazol-4-yl)-6-iodo-N1-methylbenzene-1,2-diamine (1.89 g, 5.5 mmol, 1 equiv.) in a pressure tube was added THF (5 mL) and CDI (2.67 g, 18.5 mmol, 3 equiv.). The mixture was heated to 120° C. for 30 minutes in a microwave reactor. The reaction was concentrated in vacuo and purified by HPLC to provide 5-(3,5-dimethylisoxazol-4-yl)-7-iodo-1-methyl-1H-benzo[d]imidazol-2(3H)-one.

Provenance & Evidence