化工社化工社 化学情報印刷レポート · 研究参考用
Methylamine → Benzoic acid, 2-(methylamino)-3-nitro-, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 2-fluoro-3-nitrobenzoate | HCID 13470961 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Benzoic acid, 2-(methylamino)-3-nitro-, methyl ester | HCID 59635415 | — |
反応手順
Methyl 2-fluoro-3-nitrobenzoate (25 g, 0.126 mol) was dissolved in DCM (400 ml) and to this was added Potassium carbonate (34.7 g, 0.25 mol) followed by Methylamine (20.63 ml, 0.5 mol). Reaction was stirred at room temperature under argon. Upon completion reaction was diluted with water and extracted with DCM (3×) then dried over magnesium sulfate. Solvents were removed under reduced pressure to afford methyl 2-(methylamino)-3-nitrobenzoate as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09255089B2 |
| 出典データセット | uspto-grants-2016_02 |
| ORD ID | ord-7b54cf94915f4dfb8c875f28ccffe5d3 |
| 出典メモ | uspto-grants-2016_02 |