HCID 117601879, compound → HCID 117601937, compound

Participants

Reaction Steps

Ethyl magnesiumbromide (3M, 0.61 mL, 1.84 mmol) was added to a solution of 2-(6-(3,5-dimethylisoxazol-4-yl)-2-ethoxy-1H-benzo[d]imidazol-4-yl)-2-hydroxy-2-(pyridin-2-yl)acetaldehyde (120 mg, 0.31 mmol) in methyl-THF at 0° C. After 15 min, the reaction mixture was quenched with 1M HCl, concentrated and a portion of this material was purified by reverse-phase HPLC to give the major diastereomer 4-(1,2-dihydroxy-1-(pyridin-2-yl)butyl)-6-(3,5-dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-2(3H)-one.

Provenance & Evidence