tert-butyl N-(2-hydroxypropyl)carbamate → HCID 67968139, compound

HRID 1773778Notes

Reaction equation

HRID 1773778 reaction equation
C(O[C:4]([C:6]1[NH:7][N:8]=[C:9]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:10]=1)=O)C.C(OC(=O)[NH:25][CH2:26][CH:27](O)[CH3:28])(C)(C)C.C(OC(C1N(CC(NC(OC(C)(C)C)=O)C)N=C(COC2C=CC=CC=2)C=1)=O)C.CC1CN2N=C(COC3C=CC=CC=3)C=C2C(=O)N1.CC1CN2N=C(COC3C=CC=CC=3)C=C2CN1>>[CH3:28][CH:27]1[N:7]2[N:8]=[C:9]([CH2:11][O:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:10]=[C:6]2[CH2:4][NH:25][CH2:26]1

Participants

6

Reactant 5

HCID 9920508tert-butyl N-(2-hydroxypropyl)carbamateHCID 67958408ethyl 1-{2-[(tert-butoxycarbonyl)amino]propyl}-3-(phenoxymethyl)-1H-pyrazole-5-carboxylateHCID 67960066HCID 67960066, compoundHCID 67960219HCID 67960219, compoundHCID 178469067HCID 178469067, compound

Product 1

HCID 67968139HCID 67968139, compound

Procedure

The compound was prepared from 5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester and rac-2-hydroxy-propyl-carbamic acid tert-butyl ester using the methods described in the preceding examples 11 (rac-2-(2-tert-butoxycarbonylamino-propyl)-5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester), 12 (rac-6-methyl-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one), and 13 (rac-6-methyl-2-phenoxymethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine).

Sources & evidence

ORD record
ord-477b985147ea4a39acb0f78f10af6465
Source dataset
uspto-grants-2016_02
Patent number
US09255103B2

Reaction notes

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