Acetic Acid → HCID 67295308, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 50 g (0.14 mol) of 2,4-dioxo-9-(4-propylcyclohexyl)-3-aza-spiro[5.5]undecane-1,5-dicarbonitrile, 800 ml of glacial acetic acid and 1.51 of 60% sulfuric acid is stirred at 120-125° C. for 5 days. After cooling, the batch is added to ice-water and extracted a number of times with THF/MTBE (1:1). The combined organic phases are washed with saturated sodium chloride solution and dried using sodium sulfate. The solution is concentrated to dryness, and the residue is recrystallised from acetonitrile/THF (2:1), giving (4-carboxymethyl-4′-propylbicyclohexyl-4-yl)acetic acid as a beige solid.

Provenance & Evidence