Hydrochloric Acid → HCID 67295236, compound

Participants

Reaction Steps

10.0 g (0.26 mol) of lithium aluminium hydride are suspended in 200 ml of THF, and a solution of 24.0 g (74.0 mmol) of (4-carboxymethyl-4′-propylbicyclohexyl-4-yl)acetic acid in 300 ml of THF is metered in. When the addition is complete, the mixture is stirred at RT for 1 h and at the reflux temperature for 3 h. The reaction mixture is hydrolysed using water and neutralised using dil. hydrochloric acid. The salts are filtered off, and the filtrate is diluted with MTBE. The solution is washed with saturated sodium chloride solution and dried using sodium sulfate. The solid remaining after removal of the solvents is recrystallised from acetonitrile, giving 2-[4-(2-hydroxyethyl)-4′-propylbicyclohexyl-4-yl]ethanol as a beige solid.

Provenance & Evidence