Oxalic Acid → 4-(1-methylpiperidin-4-yloxy)-2-vinyl-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate

HRID 1773864Notes

Reaction equation

HRID 1773864 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][CH:9]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[CH2:16][CH2:15][N:14]3[C:10]2=[N:11][C:12]([CH:23]=[CH2:24])=[CH:13]3)[CH2:4][CH2:3]1.[C:25]([OH:30])(=[O:29])[C:26]([OH:28])=[O:27]>CC(C)=O>[C:25]([OH:30])(=[O:29])[C:26]([OH:28])=[O:27].[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][CH:9]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[CH2:16][CH2:15][N:14]3[C:10]2=[N:11][C:12]([CH:23]=[CH2:24])=[CH:13]3)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 971Oxalic AcidHCID 867039504-(1-methylpiperidin-4-yloxy)-2-vinyl-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene

Product 1

HCID 867039514-(1-methylpiperidin-4-yloxy)-2-vinyl-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-(1-methylpiperidin-4-yloxy)-2-vinyl-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene is dissolved in acetone (1.7 mL) and oxalic acid (1 equivalent) is added. Acetone is removed under reduced pressure to afford 4-(1-methylpiperidin-4-yloxy)-2-vinyl-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate.

Workup

  1. customAcetone is removed under reduced pressure

Sources & evidence

ORD record
ord-696ef5aa3b3c483a9c5329c55da0eed2
Source dataset
uspto-grants-2016_02
Patent number
US09255101B2

Reaction notes

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