Oxalic Acid → 2-ethyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate

HRID 1773866Notes

Reaction equation

HRID 1773866 reaction equation
[CH2:1]([C:3]1[N:12]=[C:11]2[N:5]([CH2:6][CH2:7][C:8]3[CH:24]=[CH:23][CH:22]=[CH:21][C:9]=3[CH:10]2[O:13][CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[CH:4]=1)[CH3:2].[C:25]([OH:30])(=[O:29])[C:26]([OH:28])=[O:27]>CC(C)=O>[C:25]([OH:30])(=[O:29])[C:26]([OH:28])=[O:27].[CH2:1]([C:3]1[N:12]=[C:11]2[N:5]([CH2:6][CH2:7][C:8]3[CH:24]=[CH:23][CH:22]=[CH:21][C:9]=3[CH:10]2[O:13][CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[CH:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 971Oxalic AcidHCID 867039522-ethyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene

Product 1

HCID 867039532-ethyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-ethyl-4-(1-methyl piperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene is dissolved in acetone (1.7 mL) and oxalic acid (1 equivalent) is added. Acetone is removed under reduced pressure to afford 2-ethyl-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate.

Workup

  1. customAcetone is removed under reduced pressure

Sources & evidence

ORD record
ord-699f4a6f710f42cc8bc4d0bff8f6d680
Source dataset
uspto-grants-2016_02
Patent number
US09255101B2

Reaction notes

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