Oxalic Acid → 4-(1-methylpiperidin-4-yloxy)-2-phenethyl-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate

HRID 1773871Notes

Reaction equation

HRID 1773871 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][CH:9]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[CH2:16][CH2:15][N:14]3[C:10]2=[N:11][C:12]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:13]3)[CH2:4][CH2:3]1.[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33]>CC(C)=O>[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33].[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([O:8][CH:9]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[CH2:16][CH2:15][N:14]3[C:10]2=[N:11][C:12]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:13]3)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 971Oxalic AcidHCID 867039574-(1-methylpiperidin-4-yloxy)-2-phenethyl-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene

Product 1

HCID 867039584-(1-methylpiperidin-4-yloxy)-2-phenethyl-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene oxalate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-(1-methylpiperidin-4-yloxy)-2-phenethyl-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene is dissolved in acetone (0.85 mL) and oxalic acid (1 equivalent) is added. Acetone is removed under reduced pressure to afford the product as an oxalate.

Workup

  1. customAcetone is removed under reduced pressure

Sources & evidence

ORD record
ord-13650bd2651f456c869686a6e9da603c
Source dataset
uspto-grants-2016_02
Patent number
US09255101B2

Reaction notes

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