Methanesulfonic Acid → HCID 86703968, compound

Participants

Reaction Steps

To a solution of methanesulfonic acid (10 mL) in CHCl3 cooled at 0° C. is added a solution of 4-methyl-1-phenethyl-5-phenyl-imidazole-2-carbaldehyde (example 123C) (290 mg, 1 mmole) in CHCl3 (2 mL) dropwise. The reaction mixture is allowed to slowly reach room temperature and is stirred at room temperature for 1 h. The reaction mixture is poured into a solution of saturated Na2CO3 (final pH 9-10). The precipitate is filtered, washed with water and filter-dried. The residual solid is re-crystallized from hot ACN to give 2-methyl-1-phenyl-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulen-4-ol.

Provenance & Evidence