4-Benzyl-1-phenethyl-imidazole → 2-(1-methyl-1-phenyl-ethyl)-4-(1-methylpiperidin-4-yloxy)-9,10-dihydro-4H-3,10a-diaza-benzo[f]azulene
Reaction equation
I[C:2]1[N:3]=[C:4]([CH:15]=[O:16])[N:5]([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=1.C(C1N=C[N:27]([CH2:29][CH2:30][C:31]2[CH:36]=[CH:35]C=CC=2)[CH:28]=1)C1C=CC=CC=1.C[C:38]([C:46]1N=CNC=1)([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[CH3:39]>>[CH3:46][C:38]([C:2]1[N:3]=[C:4]2[N:5]([CH2:7][CH2:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH:15]2[O:16][CH:31]2[CH2:30][CH2:29][N:27]([CH3:28])[CH2:35][CH2:36]2)[CH:6]=1)([C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1)[CH3:39]Participants
4
Procedure
The compound is synthesized using the method described in example 2A, 2B and 110B starting from 4-(1-methyl-1-phenylethyl) imidazole (example 207B).
Workup
- customThe compound is synthesized
Sources & evidence
- ORD record
- ord-b537546617db4e6ab2b7ed8fc9cbd412
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09255101B2
Reaction notes
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