反应详情

To a solution of 3-methyl-3-phenyl-butan-2-one (example 207D) (8.7 g, 53.6 mmoles) in ACN (150 mL) is added hydroxy(tosyloxy)iodobenzene (22.1 g, 56.3 mmoles). The reaction mixture is heated at reflux for 5 hours. Solvent and volatiles are removed under reduced pressure. The residue is purified by silica gel chromatography eluting with (heptane:AcOEt) (90:1) to give toluene-4-sulfonic acid 3-methyl-2-oxo-3-phenyl-butyl ester.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 5 hours
3. customSolvent and volatiles are removed under reduced pressure
4. customThe residue is purified by silica gel chromatography
5. washeluting with (heptane:AcOEt) (90:1)