N-Iodosuccinimide → HCID 86704015, compound

Participants

Reaction Steps

To a solution of 4-phenyl-1H-imidazole (4.75 g, 33 mmoles) in CH2Cl2 (250 mL) is added N-iodosuccinimide (6.75 g, 30 mmoles). After 2 hours at room temperature, CH2Cl2 is removed under reduced pressure. The residual solid is triturated in hot ACN (150 mL), cooled down to room temperature and filtered. The white-off solid is triturated in hot ACN (60 mL), cooled down to room temperature and stirred overnight at room temperature. After a filtration, 5-iodo-4-phenyl-1H-imidazole is obtained.

Provenance & Evidence