Hydrochloric Acid → HCID 89537957, compound

Participants

Reaction Steps

22.0 g (75.0 mmol) of 5-methyl-3-(methylthio)-2-(trifluoroacetylamino)benzoic acid and 9.44 g (225 mmol) of lithium hydroxide monohydrate were heated under reflux in a mixture of 200 ml of methanol and 30 ml of water for 4 h. For work-up, the contents were cooled and freed of the solvents. The residue was taken up in water and the mixture was acidified to pH<3 with dilute hydrochloric acid. The mixture was stirred at a temperature of 0° C.-5° C. for 30 minutes and then filtered. 15.0 g of 2-amino-5-methyl-3-(methylthio)benzoic acid of a purity of >95% by weight were obtained as residue.

Provenance & Evidence