Ammonia → 6-Chloroquinazoline-2,4(1H,3H)-diimine

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-amino-5-chlorobenzonitrile (1.07 g, 7.0 mmol), chloroformamidine hydrochloride (1.6 g, 14 mmol), sulfolane (0.5 ml) and dimethylsulfone (3 g) was heated at 165° C. for 30 minutes. Then, water (30 ml) was added to the reaction mixture. The pH was adjusted to 7-8 by the addition of a 33% aqueous ammonia solution in water. The precipitate was collected by filtration, washed with water and dried over P2O5, yielding the title compound as a yellowish solid (1.35 g, yield: 99%) which was characterized by its mass spectrum as follows: MS (m/z): 195 ([M+H]+, 100).

Provenance & Evidence