Acetic Anhydride → HCID 178488518, compound

Participants

Reaction Steps

A suspension of the crude 2-amino-6-(3,4-dimethoxyphenyl)-4-hydroxyquinazoline from example 5 (3.0 g, 10 mmol) in acetic anhydride (20 ml) was refluxed for 40 minutes. After concentration under reduced pressure, the residue was purified by silica gel flash chromatography, the mobile phase being a mixture of methanol and dichloromethane (in a ratio of 1:40), yielding the title compound as a white solid (3.05 g, yield: 90%) which was characterized by its mass spectrum as follows: MS (m/z): 340 ([M+H]+, 100).

Provenance & Evidence